A virus could also mutate in ways that could lead to illnesses that tend to be more severe-or milder. Some mutations can make a vaccine less able to fend off infections, or they can make the monoclonal antibodies often used to treat COVID-19 less effective, says Luis Ostrosky, MD, a professor of infectious diseases at the McGovern Medical School at UTHealth in Houston and a fellow of the Infectious Diseases Society of America. For example, the alpha variant had four mutations to the spike protein, delta had 10, and omicron has more than 30.
Omicron has far more changes to the spike protein-the portion of the virus that infects human cells-than any of the previous concerning variants, says Gregory Poland, MD, director of the Vaccine Research Group at the Mayo Clinic in Rochester, Minn. It can also happen if the new variant is better able to evade the immune system protection provided by prior infection or vaccination, which could help it spread among people who would otherwise be protected. This can happen if the new variant creates a higher viral load, increasing the chances that contagious particles make it to another person. Increased transmissibility can make these variants-a word used to define a virus with a particular set of mutations-dominate in a certain region or even around the world, as happened with delta and subsequently with omicron. Most of these small changes are inconsequential, and they are just as likely to make a virus less likely to transmit as they are to make it more so.īut sometimes a virus acquires a set of mutations that makes it more likely to spread. Passing a school bus.Viruses like SARS-CoV-2 continually mutate as they replicate.
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